Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Shaun Webb
PROVIDER: E-GEOD-53489 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Genome biology 20140904 9
<h4>Background</h4>Trimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity-dependent manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in targeting the Set1 complex to CpG islands in mammals. In mouse embryonic stem cells, Cfp1 is necessary for H3K4me3 accumulation at constitutively active gene promoters, but is not required to maintain steady-state transcription of the associ ...[more]