Characterization and comparison of lactating mouse and bovine mammary gland miRNomes

ABSTRACT: Background: The mammary gland is a dynamic organ that undergoes important physiological changes during reproductive cycles. Until now, data regarding the characterisation of miRNA in the mammary gland have been scarce and mainly focused on their abnormal expression in breast cancer. Our goal was to characterise the microRNA (miRNA) involved in mechanisms regulating the mammary function, with particular focus on the lactation stage Methodology/principal findings: Using high-throughput sequencing technology, an exhaustive repertoire of miRNA (miRNome) expressed in mouse and bovine mammary glands during established lactation was identified, characterised and compared. Furthermore, in order to obtain more information on miRNA loading in the RNA-induced silencing complex (RISC), the miRNome was

ORGANISM(S): Bos taurus

SUBMITTER: Sylvain Marthey 

PROVIDER: E-GEOD-53511 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress