Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

ABSTRACT: CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones, we identified the surface markers CD49b and lymphocyte activation gene 3 (LAG-3) as being stably and selectively coexpressed on mouse and human Tr1 cells. We showed the specificity of these markers in mouse models of intestinal inflammation and helminth infection and in the peripheral blood of healthy volunteers. The coexpression of CD49b and LAG-3 enables the isolation of highly suppressive human Tr1 cells from in vitro anergized cultures and allows the tracking of Tr1 cells in the peripheral

ORGANISM(S): Homo sapiens

SUBMITTER: Mauro Pala 

PROVIDER: E-GEOD-53514 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress