Transcription profiling of human solid cancers reveals a precisely regulated gene expression cassette potently modulates metastasis and survival

ABSTRACT: Successful carcinogenesis involves the integration of both pro- and anti-oncogenic pathways. We postulated that genes critical for balancing these opposing pathways are likely to be precisely controlled in tumors, since even subtle alterations in their activity might cause substantial alterations in tumor growth and survival. Using a novel genomic approach, we identified a 48-gene “Poised Gene Cassette” (PGC) showing tight regulation specifically in human cancers but not in corresponding nonmalignant tissues. We show, using a wide variety of in vitro and in vivo approaches, that small alterations in PGC expression are consistently associated with significant differences in experimental metastasis and patient survival, and we demonstrate a direct functional role for five PGC genes (p53C

ORGANISM(S): Homo sapiens

SUBMITTER: Kun Yu 

PROVIDER: E-GEOD-5364 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress