Dual RNA-seq of parasite and host reveals gene expression dynamics during filarial worm-mosquito interactions

ABSTRACT: Parasite biology, by its very nature, cannot be understood without integrating it with that of the host, nor can the host response be adequately explained without considering the activity of the parasite. However, due to experimental limitations, molecular studies of parasite-host systems have been predominantly one-sided investigations focusing on either of the partners. Here we conduct a joint dual RNA-seq time course analysis of filarial parasite and host mosquito to better understand the parasite processes underlying development in, and interaction with, the host tissue from the establishment of infection to the emergence of infective-stage larva. Using the Brugia malayi-Aedes aegypti system, we report the parasite gene transcription dynamics, which exhibit a highly ordered development

ORGANISM(S): Aedes aegypti

SUBMITTER: Bruce Christensen 

PROVIDER: E-GEOD-53664 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress