Conserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response

ABSTRACT: Discriminating pathogenic bacteria from energy-harvesting commensals is key to host immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the role of this nutrient-sensing pathway in the Caenorhabidits elegans innate immune response. Using whole genome transcriptional profiling, O-GlcNAc cycling mutants exhibited deregulation of unique stress- and immune-responsive genes as well as genes shared with the p38 MAPK/PMK-1 pathway. Moreover, genetic analysis showed that deletion of O-GlcNAc transferase (ogt-1) yielded animals hypersensitive to the human pathogen S. aureus but not to P. aeruginosa. Genetic interaction studies further revealed that nutrient-responsive OGT-1 acts through the conserved ß-catenin (BAR-1) pathway and in conc

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: WeiPing Chen 

PROVIDER: E-GEOD-53732 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress