Differential transcription of fathead minnow immune-related genes following infection with an emerging pathogen of ectothermic vertebrates, Frog virus 3

ABSTRACT: Frog virus 3 (FV3) and other ranaviruses are responsible for an increasing number of die-offs involving wild, farmed, and captive amphibians, fish, and reptiles. Studies in Lithobates pipiens (Leopard frogs) and Xenopus laevis (African clawed frog) indicate that embryos and tadpoles are more likely to succumb to FV3 infection than adult animals. The heightened susceptibility of embryos and tadpoles to ranaviral disease likely reflects the immaturity of their immune system. To ascertain which elements of the immune system respond to ranavirus infection, we explored cellular transcriptional responses following infection of fathead minnow (Pimephales promelas) cells with either wild type (wt) FV3 or a knock out (KO) mutant targeting the 18kDa immediate early gene (18K). At 8 hr post inf

ORGANISM(S): Pimephales promelas

SUBMITTER: Natalia Vinas 

PROVIDER: E-GEOD-53739 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress