Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories

ABSTRACT: Remembrances of traumata range among the most enduring forms of memories. Despite the elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term traumatic memories are scarce. The most efficacious treatments to diminish recent (i.e., day-old) traumata capitalize on memory updating mechanisms during reconsolidation that are initiated upon memory recall. Here, we show that in mice successful reconsolidation-updating paradigms for recent memories fail to attenuate remote (i.e., month-old) ones. We find that whereas recent memory recall induces a limited period of hippocampal neuroplasticity mediated, in part, by S-nitrosylation of HDAC2 and histone acetylation, such plasticity is absent for remote memories. However, by using an HDAC2-targeting inhibitor (HD

ORGANISM(S): Mus musculus

SUBMITTER: Li-Huei Tsai 

PROVIDER: E-GEOD-53794 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress