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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Whole blood DNA methylation samples from HIV positive men [2012 study]

ABSTRACT: Genome wide DNA methylation profiles of whole blood from HIV positive men. The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 480,000 CpGs. Dataset included 24 subjects from the USA. This data set was used as validation set for studying the effect of HIV viral load on host DNA methylation levels. Bisulphite converted DNA from the 24 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip. Subjects had different levels of HIV viral load. This dataset reports DNA methylation data set on 24 subjects that were generated in 2012 (while the other data set of 120 subjects reports DNA meth data generated in 2013). Details on what each sample characteristics and their values represent are provided in the 'characteristics_readme.txt' file.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Horvath

PROVIDER: E-GEOD-53841 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

HIV-1 Infection Accelerates Age According to the Epigenetic Clock.

Horvath Steve S Levine Andrew J AJ

The Journal of infectious diseases 20150512 10

<h4>Background</h4>Infection with human immunodeficiency virus type 1 (HIV) is associated with clinical symptoms of accelerated aging, as evidenced by the increased incidence and diversity of age-related illnesses at relatively young ages and supporting findings of organ and cellular pathologic analyses. But it has been difficult to detect an accelerated aging effect at a molecular level.<h4>Methods</h4>Here, we used an epigenetic biomarker of aging based on host DNA methylation levels to study ...[more]

PMID: 25969563

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