MiR-27b synergizes with anticancer drugs

ABSTRACT: Drug resistance, caused by complex and redundant mechanisms, is a major obstacle in cancer treatment, especially in liver and kidney cancers. Combinational therapy of miRNAs, which concurrently target multiple pathways, with anticancer drugs represent a new strategy to improve the drug response. By a systems approach, we identified that miR-27b, a miRNA deleted in liver and kidney cancers, sensitizes cancer cells to a broad spectrum of anticancer drugs in vitro and in vivo. Two samples transfected with nontarget miRNA control or miR-27b mimics followed by 48 hours doxorubicin treatment

ORGANISM(S): Homo sapiens

SUBMITTER: Lijian Hui 

PROVIDER: E-GEOD-53872 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress