B-myb is Essential Regulator of Hematopoietic Stem Cell and Myeloid Progenitor Cell Development

ABSTRACT: The B-myb (MYBL2) gene is a member of the MYB family of transcription factors and is involved in cell cycle regulation, DNA replication and maintenance of genomic integrity. However, its function during adult development and hematopoiesis is unknown. We show here that conditional inactivation of B-myb in vivo results in depletion of the HSC pool, leading to profound reductions in mature lymphoid, erythroid and myeloid cells. This defect is autonomous to the bone marrow and is first evident in the HSCs, which accumulate in the S and G2/M phases. B-myb inactivation also causes defects in the myeloid progenitor compartment and results in an accumulation of GMPs. Microarray studies indicate that B-myb null LKS+ cells differentially express genes that direct myeloid lineage development and comm

ORGANISM(S): Mus musculus

SUBMITTER: Stacey Baker 

PROVIDER: E-GEOD-53875 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress