Transcription profiling of human brain tissue from subjects with bipolar disorder and healthy controls

ABSTRACT: Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex) from patients with bipolar disorder and matched healthy controls. A cohort of 70 subjects was investigated and the final analysis included 30 bipolar and 31 control subjects. Differences between disease and control groups were identified using a rigorous statistical analysis with correction for confounding variables and multiple testing.

ORGANISM(S): Homo sapiens

SUBMITTER: Sabine Bahn 

PROVIDER: E-GEOD-5388 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress