K1 and K15 of Kaposi sarcoma-associated herpes virus are functional homologues of latent membrane protein 2A of Epstein-Barr virus

ABSTRACT: LMP2A of Epstein-Barr virus is a receptor that mimics an activated B cell receptor, BCR. K1 and K15, related receptors of Kaposi sarcoma-associated herpes virus, KSHV, are expressed in virus-associated tumors but their functions are less obvious. We addressed this uncertainty with mutant EBVs encoding the KSHV genes K1 or K15 in lieu of LMP2A and infected primary human B cells with them. K1 and K15 encoded proteins appear to have noncomplementing redundant functions in this model but our findings suggest that both KSHV proteins can replace LMP2AM-bM-^@M-^Ys key activities contributing to the survival, activation and proliferation of B cells. We infected unsorted B cells with the four virus stocks, wt EBV, K1 EBV, K15 EBV or M-NM-^TLMP2A EBV, adjusted to yield similar rates of EBV-activated

ORGANISM(S): Homo sapiens

SUBMITTER: Dominik Lutter 

PROVIDER: E-GEOD-53914 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress