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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Gallus gallus

SUBMITTER: Jiao Hu

PROVIDER: E-GEOD-53932 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host response.

Hu Jiao J Mo Yiqun Y Wang Xiaoquan X Gu Min M Hu Zenglei Z Zhong Lei L Wu Qiwen Q Hao Xiaoli X Hu Shunlin S Liu Wenbo W Liu Huimou H Liu Xiaowen X Liu Xiufan X

Journal of virology 20150128 8

<h4>Unlabelled</h4>PA-X is a newly discovered protein that decreases the virulence of the 1918 H1N1 virus in a mouse model. However, the role of PA-X in the pathogenesis of highly pathogenic avian influenza viruses (HPAIV) of the H5N1 subtype in avian species is totally unknown. By generating two PA-X-deficient viruses and evaluating their virulence in different animal models, we show here that PA-X diminishes the virulence of the HPAIV H5N1 strain A/Chicken/Jiangsu/k0402/2010 (CK10) in mice, ch ...[more]

PMID: 25631083

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Expression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses [24 hours post infection]

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