Gene expression profiles in gastric mucosa from a transgenic mice infected with H. pylori and immunized with BabA

ABSTRACT: Many vaccination studies have revealed various degrees of protection in mouse models. However, the mechanism of protection is not fully understood. The aim of this study was to identify genes specifically expressed in H. pylori infection and prophylactic immunized mice. A prophylactic immunization with purified protein of H. pylori BabA combining with the mucosal CTA1-DD adjuvant was performed in a-1,3/4-fucosyltransferase transgenic FVB/N mice. Gene expression profile was analysed from the gastric mucosa among untreated, the infected and immunized mice. There were a set of genes were upregulated or downregulated respectively, in infected mice as compared with untreated mice. These include the adipokines released form adipose tissue, adhesion molecules and actin cytoskeletal rearragemet as

ORGANISM(S): Mus musculus

SUBMITTER: Qiang Pan-Hammarström 

PROVIDER: E-GEOD-5398 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress