Runx2-mediated gene regulation is affected by its genomic occupancy

ABSTRACT: Osteogenesis is a highly regulated developmental process and continues during the turnover and repair of mature bone. Runx2, the master regulator of osteoblastogenesis, directs a transcription program essential for bone formation through both genetic and epigenetic mechanisms. While individual Runx2 gene targets have been identified, further insights into the broad spectrum of Runx2 functions required for osteogenesis are needed. By performing genome-wide characterization of Runx2 binding at the three major stages of osteoblast differentiation: proliferation, matrix deposition and mineralization, we identified Runx2-dependent regulatory networks driving bone formation. Using chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-Seq) over the course of these stages, we

ORGANISM(S): Mus musculus

SUBMITTER: Jane Lian 

PROVIDER: E-GEOD-53982 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress