Microarray profiling of PFC, HPC and STR from subjects with schizophrenia, bipolar, MDD or control

ABSTRACT: Schizophrenia is a complex psychiatric disorder encompassing a range of symptoms and etiology dependent upon the interaction of genetic and environmental factors. Several risk genes, such as DISC1, have been associated with schizophrenia as well as bipolar disorder (BPD) and major depressive disorder (MDD), consistent with the hypothesis that a shared genetic architecture could contribute to divergent clinical syndromes. The present study compared gene expression profiles across three brain regions in post-mortem tissue from matched subjects with schizophrenia, BPD or MDD and unaffected controls. Post-mortem brain tissue was collected from control subjects and well-matched subjects with schizophrenia, BPD, and MDD (n=19 from each group). RNA was isolated from hippocampus, Brodmann Are

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Lanz 

PROVIDER: E-GEOD-53987 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress