Genome-wide profiling of human gene in HPV16E2 protein expressing human keratinocyte

ABSTRACT: In the early stage of human papillomavirus (HPV) infection, E2 and E6 proteins are expressed and elicit specific immune response to clear cervical lesion. HPV E6 protein can reduce type I interferon (IFN) including IFN-? that involves in immune evasion and HPV persistence. To evaluate the role of E2 protein in modulation of the expression of cellular genes as well as innate immune associated genes in HPV associated cervical cancer, genome-wide expression profiling of human primary keratinocytes (HPK) harbouring HPV16 E2 and HPV18 E2 was investigated using microarray assay and innate immune associated genes were analyzed. These results indicated that HPV E2s altered cellular gene expression including immune associated genes. Altered cellular signaling pathways in HPK expressing HPV E2s base

ORGANISM(S): Homo sapiens

SUBMITTER: Nuchsupha Sunthamala 

PROVIDER: E-GEOD-54008 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress