Klinefelter Syndrome testicular gene expression profile by a whole genome microarray approach.

ABSTRACT: Objective: Klinefelter Syndrome (KS) is the most common sexual chromosome abnormality (47,XXY) and represents the first genetic cause of male infertility. The mechanisms leading to KS testis degeneration are still unclear and no therapy is so far available for affected patients. The present study is aimed to unravel information about molecules playing a key role in the disruption of the spermatogenesis. Design: Gene expression profiles analysis of KS azoospermic testis versus normal testis, could provide useful information about the molecular basis of the alteration of the spermatogenesis. Materials and Methods: Transcriptome analysis was performed carrying out gene expression profile by a whole genome microarray approach on testis biopsies obtained from 6 azoospermic non-mosaic KS men and

ORGANISM(S): Homo sapiens

SUBMITTER: Valentina Gatta 

PROVIDER: E-GEOD-54023 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress