Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: ari itoh
PROVIDER: E-GEOD-54050 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of experimental medicine 20131014 11
Pulmonary alveolar proteinosis (PAP) results from a dysfunction of alveolar macrophages (AMs), chiefly due to disruptions in the signaling of granulocyte macrophage colony-stimulating factor (GM-CSF). We found that mice deficient for the B lymphoid transcription repressor BTB and CNC homology 2 (Bach2) developed PAP-like accumulation of surfactant proteins in the lungs. Bach2 was expressed in AMs, and Bach2-deficient AMs showed alterations in lipid handling in comparison with wild-type (WT) cell ...[more]