Expression profiles of 186-gene signature in U.S. hepatitis C virus (HCV)-related liver cirrhosis

ABSTRACT: OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genomic and clinical variables to identify patients at high risk of disease progression. DESIGN: We developed a prognostic index, comprised of a 186-gene signature validated in our previous genome-wide profiling study, bilirubin (>1?mg/dL) and platelet count (<100?000/mm3), in an Italian HCV cirrhosis cohort (training cohort, n=216, median follow-up 10?years). The gene signature test was implemented using a digital transcript counting (nCounter) assay specifically developed for clinical use and the

ORGANISM(S): Homo sapiens

SUBMITTER: Yujin Hoshida 

PROVIDER: E-GEOD-54100 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress