Genome-wide analysis of androgen receptor (AR) SUMOylation effects on gene expression (PC-3).

ABSTRACT: Androgen receptor (AR) plays an important regulatory role during prostate cancer development. ARM-bM-^@M-^Ys transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications. To study the role of the AR SUMOylation in genuine chromatin environment, we compared androgen-regulated gene expression and AR chromatin occupancy in PC-3 prostate cancer and HEK293 cell lines stably expressing wild-type (wt) or SUMOylation site-mutated AR (AR-K386R,K520R). Our genome-wide gene expression analyses reveal that the SUMOylation modulates the AR function in a target gene and pathway selective manner. The transcripts that are differentially regulated by androgen and SUMOylation are linked to cellular movement, cell death, cellular proliferation, cellular developmen

ORGANISM(S): Homo sapiens

SUBMITTER: PM-CM-$ivi Sutinen 

PROVIDER: E-GEOD-54104 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress