Genome-wide DNase hypersensitive sites during osteoclastogenesis

ABSTRACT: Clarification of the mechanisms underlying osteoclast differentiation enable us to understand the physiology of bone metabolism as well as the pathophysiology of bone diseases, such as osteoporosis. Recently, it has been reported that epigenetics can determine the cell fate and regulate cell type specific gene expression. However, little is known about epigenetics during osteoclastogenesis. To reveal a part of epigenetics, especially focused on chromatin dynamics, during early osteoclastogenesis and identify novel transcription factors involved in osteoclastogenesis, we investigated genome-wide analysis of open chromatin during receptor activator of nuclear factor-M-NM-:B ligand (RANKL)-induced osteoclastogenesis using DNase I hypersensitive sites sequencing (DNase-seq). DNase-seq was perf

ORGANISM(S): Mus musculus

SUBMITTER: Yuuki Imai 

PROVIDER: E-GEOD-54139 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress