Genome-wide sequencing of small RNAs of Echinococcus granulosus shows microRNAs may be involved life cycle stage development and differentiation

ABSTRACT: MicroRNAs (miRNAs) are important post-transcriptional regulators which control growth and development in eukaryotic animals. The cestode Echinococcus granulosus has a complex life-cycle involving different development stages but the mechanisms underpinning this development, including the involvement of miRNAs, remain unknown. Using Illumina deep-sequencing technology, we sequenced at the genome-wide level three small RNA populations from the adult, protoscolex and cyst membrane of E. granulosus. A total of 94 miRNA candidates (coding 100 mature miRNAs and 30 miRNA*s) were predicted by a computational pipeline, of which 25 mature miRNAs and 2 miRNA*s were identified experimentally. Through comparison of expression profiles, we found 48 mature miRNAs and 17 miRNA*s expressed in different pat

ORGANISM(S): Echinococcus granulosus

SUBMITTER: Yun Bai 

PROVIDER: E-GEOD-54180 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress