CD40-mediated amplification of local immunity by keratinocytes in impaired by HPV

ABSTRACT: The interaction between the transmembrane glycoprotein surface receptor CD40 expressed by skin keratinocytes (KCs) and its T cell-expressed ligand CD154 was suggested to exacerbate inflammatory skin diseases. However, the full spectrum of CD40-mediated effects by KCs underlying this observation is unknown. Therefore, changes in gene expression after CD40 ligation of KCs were studied by microarrays. CD40-mediated activation for 2 hours stimulated the expression of a coordinated network of immune-involved genes strongly interconnected by IL8 and TNF, while after 24 hours anti-proliferative and anti-apoptotic genes were upregulated. CD40 ligation stimulated the production of chemokines that attracted lymphocytes and myeloid cells from peripheral blood mononuclear cells (PBMCs). Thus, CD40-med

ORGANISM(S): Homo sapiens

SUBMITTER: Bart Tummers 

PROVIDER: E-GEOD-54181 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress