Global analysis of cell cycle gene expression of the legume symbiont Sinorhizobium meliloti

ABSTRACT: In α-proteobacteria, strict regulation of cell cycle progression is necessary for the specific cellular differentiation required for adaptation to diverse environmental niches. The symbiotic lifestyle of Sinorhizobium meliloti requires a drastic cellular differentiation that includes genome amplification. To achieve polyploidy, the S. meliloti cell cycle program must be altered to uncouple DNA replication from cell division. In the α-proteobacterium Caulobacter crescentus, cell cycle regulated transcription plays an important role in control of cell cycle progression but this has not been demonstrated in other α-proteobacteria. Here we describe a robust method for synchronizing cell growth that enabled the first global analysis of S. meliloti cell cycle regulated gene expression. The objec

ORGANISM(S): Sinorhizobium meliloti 1021

SUBMITTER: Nicole De Nisco 

PROVIDER: E-GEOD-54208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress