Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study

ABSTRACT: Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent environment for opportunistic infection by augmenting virulence and suppressing the host defense. Presumably, extraterrestrial infection may trigger potentially novel bionetworks different from the terrestrial equivalent, which could only be probed by investigating the host-pathogen relationship with minimum terrestrial bias. Towards this objective, we strategically engineered a cell culture module equipped with a feedback controlled semi-automated platform to expose human endothelial cells to lipopolysaccharide (LPS). The assay was carried out in the STS-135 space shuttle, and a concurrent ground study constituted the baseline. Tr

ORGANISM(S): Homo sapiens

SUBMITTER: Meskerem Jibitu 

PROVIDER: E-GEOD-54213 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress