Expression data of articular and growth plate cartilage zones in 10-day-old rat proximal tibial epiphysis

ABSTRACT: Articular and growth plate cartilage have comparable structures consisting of three distinct layers of chondrocytes, suggesting similar differentiation programs and therefore similar gene expression profiles. To address this hypothesis and to explore transcriptional changes that occur during the onset of articular and growth plate cartilage divergence, we used microdissection of 10-day-old rat proximal tibial epiphyses, microarray analysis, and bioinformatics to compare gene expression profiles in individual layers of articular and growth plate cartilage. We found that many genes that were spatially upregulated in intermediate/deep zone of articular cartilage were also spatially upregulated in resting zone of growth plate cartilage (overlap greater than expected by chance, P < 0.001). In

ORGANISM(S): Rattus norvegicus

SUBMITTER: Michael Chau 

PROVIDER: E-GEOD-54216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress