Hippocampal neuronal dematuration as a common effect of antidepressant treatments

ABSTRACT: The dentate gyrus (DG) of the hippocampus is one of major targets for antidepressant treatments. Our recent research has revealed that selective serotonin reuptake inhibitor (SSRI) treatment causes a long-lasting change in the phenotypes of mature dentate granule neurons to immature state in adult mouse DG. However, it is unknown whether this M-bM-^@M-^\dematurationM-bM-^@M-^] of DG is a common effect of antidepressant treatments and what mechanisms underlie it. Using electroconvulsive stimulation (ECS), a model of highly effective and fast-acting antidepressant therapy, here we show that neural stimulation via ECS induces rapid and lasting dematuration of granule neurons in DG. A single or few times of stimulation transiently reduced mature marker expression and mature synaptic functions.

ORGANISM(S): Mus musculus

SUBMITTER: Eri Segi-Nishida 

PROVIDER: E-GEOD-54307 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress