Transcriptome Sequencing from Diverse Human Populations Reveals Differentiated Regulatory Architecture

ABSTRACT: To understand the full range of expression variation, alternative splicing, and the genetics of regulatory variation in humans, we have sequenced the genomes, exomes, and transcriptomes of 45 individuals in the Human Genome Diversity Panel (HGDP) from seven worldwide populations that span the geographic breadth of human migration history. We find few genes that are systematically differentially expressed among populations. Further, allelic expression analysis indicates that previously mapped common regulatory variants identified in eight HapMap3 populations have similar effects across HGDP populations, suggesting that the cellular effects of common variants are shared even across very diverse populations. In contrast, comparisons of alternative splicing across pairwise populations reveal h

ORGANISM(S): Homo sapiens

SUBMITTER: Carlos Bustamante 

PROVIDER: E-GEOD-54308 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress