Microarray analysis of breast cancer cell lines with different levels of P-cadherin expression treated with the anti-cancer bacterial protein azurin

ABSTRACT: We performed a microarray analysis to compare the expression profile of azurin treated and untreated with different P-cadherin expression levels. We also compared the differentially expressed genes regulated by P-cadherin overexpression. Both cell lines presented an up-regulation of apoptosis mediated by p53 protein, endocytosis and vesicle-mediated transport. Conversely, invasive MCF-7/AZ.Pcad cells treated with azurin presented a decreased expression of genes associated with cell surface receptors and signal transduction, as well as genes associated with biological adhesion and migration. Azurin is a bacterial protein from Pseudomonas aeruginosa which exerts an inhibitory activity in cancer cells. In P-cadherin-overexpressing models, a bad prognosis marker in breast cancer increasing inv

ORGANISM(S): Homo sapiens

SUBMITTER: Nuno Bernardes 

PROVIDER: E-GEOD-54319 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress