Impact of monomeric and oligomeric flavanols (MOF) consumption on the gene expression profile of leukocytes (human)

ABSTRACT: Background: In a recent intervention study, the daily supplementation with 200mg monomeric and oligomeric flavanols (MOF) from grape seeds for 8 weeks revealed a vascular health benefit in male smokers. The objective of the present study was to determine the impact of MOF consumption on the gene expression profile of leukocytes and to assess changes in DNA methylation. Methodology/Principal Findings: Gene expression profiles were determined using whole genome microarrays (Agilent) and DNA methylation was assessed using HumanMethylation450 BeadChips (Illumina). MOF significantly modulated the expression of 869 genes. The majority of the affected genes are involved in chemotaxis, cell adhesion, cell infiltration or cytoskeleton organisation, suggesting lower immune cell adhesion to endotheli

ORGANISM(S): Homo sapiens

SUBMITTER: Dragan MILENKOVIC 

PROVIDER: E-GEOD-54325 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress