An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.

ABSTRACT: The regulatory logic underlying global transcriptional programs controlling development of visceral organs like the pancreas remains undiscovered. Here, we profiled gene expression in 12 purified populations of fetal and adult pancreatic epithelial cells representing crucial progenitor cell subsets, and their endocrine or exocrine progeny. Using probabilistic models to decode the general programs organizing gene expression, we identified co-expressed gene modules in cell subsets that revealed patterns and processes governing progenitor cell development, lineage specification, and endocrine cell maturation. Module network analysis linked established regulators like Neurog3 to unrecognized roles in endocrine secretion and protein transport, and nominated multiple candidate regulators of panc

ORGANISM(S): Mus musculus

SUBMITTER: Seung Kim 

PROVIDER: E-GEOD-54374 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress