Expression data from induced pluripotent stem cell-derived endothelial cells from healthy and diet-induced obesity mice

ABSTRACT: Little is known about the function of induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) generated from diabetics, as this could potentially limit subsequent therapeutic use in this patient population. Here, we demonstrate that iPSC-ECs derived from diet-induced obesity (DIO) mice exhibit evidence of endothelial dysfunction. We also observed that mice receiving intramuscular (IM) injections of DIO iPSC-ECs had significantly decreased reperfusion following hindlimb ischemia compared to mice administered with iPSC-ECs from control mice. Hindlimb sections revealed increased muscle atrophy and presence of inflammatory cells in mice receiving iPSC-ECs from DIO mice. When pravastatin was administered to mice receiving DIO iPSC-ECs, a significant increase in reperfusion was observ

ORGANISM(S): Mus musculus

SUBMITTER: Nicholas Mordwinkin 

PROVIDER: E-GEOD-54387 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress