Expression data from control infected and H-RASG12V infected IMR90 cells.

ABSTRACT: Cellular senescence is a stable proliferation arrest associated with an altered secretory pathway, the Senescence-Associated Secretory Phenotype (SASP). However, cellular senescence is initiated by diverse molecular triggers, such as activated oncogenes and shortened telomeres, and is associated with varied and complex physiological endpoints, such as tumor suppression and tissue aging. The extent to which distinct triggers activate divergent modes of senescence that might be associated with different physiological endpoints is largely unknown. To begin to address this, we performed gene expression profiling to compare the senescence programs associated with two different modes of senescence, oncogene-induced senescence (OIS) and replicative senescence (RS [in part caused by shortened telo

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Adams 

PROVIDER: E-GEOD-54402 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress