Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Gangqing Hu
PROVIDER: E-GEOD-54436 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Scientific reports 20160627
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important roles in modulating hepatic circadian rhythmicity and aging. Sirt1-deficient mice exhibited profound premature aging and enhanced acetylation of histone H4 on lysine16 (H4K16) in the promoter of Per2, th ...[more]