Transcription profiling of rat organ of Corti (OC), modiolus (MOD) and stria vascularis (SV) of newborns

ABSTRACT: The aim of this study was to characterize the basal expression of OC, MOD and SV of newborn rats (3-5 day old) and its changes by short–term cultivation (24 hrs) and mild hypoxia (5 hrs). Three varieties of tissue samples were analyzed (i) Freshly prepared tissue, used as control; (ii) cultures held under normoxic conditions and (iii) cultures exposed during cultivation to 5 h hypoxia. The gene expression was analyzed using the Affymetrix GeneChip RN-U34. The functional specificity of the cochlea regions are well reflected by the gene expression pattern. For example, the basal expression of Organ of Corti is characterized by genes involved in potassium and calcium homeostasis. The MOD is characterized by genes involved in regulation of maturation of neuronal cells. The SV is characteriz

ORGANISM(S): Rattus norvegicus

SUBMITTER: Johann Gross 

PROVIDER: E-GEOD-5446 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress