MiR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy (mRNA)

ABSTRACT: MicroRNA (miRNA) expression profiling identified miR-638 as one of the most significantly overexpressed miRNAs in metastatic lesions compared with primary melanomas. miR-638 enhanced the tumourigenic properties of melanoma cells in vitro and lung colonization in vivo. mRNA expression profiling of miR-638 and antagomir-transduced cells identified new candidate genes as miR-638 targets, the majority of which is involved in p53-mediated apoptosis regulation. miR-638 depletion stimulated expression of p53 and its downstream target genes and induced apoptosis and autophagy in melanoma cells. miR-638 promoter analysis revealed transcription factor associated protein 2-? (TFAP2A) as a direct negative regulator of miR-638. Further analyses provided strong evidence for a double negative regulatory

ORGANISM(S): Homo sapiens

SUBMITTER: Animesh Bhattacharya 

PROVIDER: E-GEOD-54493 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress