Transcription profiling of human alveolar epithelial cell line infected with EBV (A-Akata) revals alveolar epithelial cell injury with EBV upregulates TGF-beta1 expression

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a refractory and lethal interstitial lung disease characterized by alveolar epithelial cells apoptosis, fibroblast proliferation and extra-cellular matrix proteins deposition. Epstein - Barr virus (EBV) has previously been localised to alveolar epithelial cells of IPF patients. In this study we utilised a microarray based differential gene expression analysis strategy to identify potential molecular drivers of EBV associated lung fibrosis. We employed an alveolar epithelial cell line infected with EBV (A-Akata). Lytic phase infection induced in the A-Akata cells by TPA/BA treatment resulted in increase of TGFbeta1 and TIEG1 mRNA expression. Treatment of the A-Akata cells with ganciclovir,; resulted in a down regulation of both TIEG1 and TGFbeta1 expr

ORGANISM(S): Homo sapiens

SUBMITTER: Andrea Patricelli Malizia 

PROVIDER: E-GEOD-5450 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress