Whole blood transcriptome of survivors and nonsurvivors of sepsis

ABSTRACT: There is currently no reliable tool available to measure immune dysfunction in septic patients in the clinical setting. This proof-of-concept study assesses the potential of gene expression profiling of whole blood as a tool to monitor immune dysfunction in critically ill septic patients. Whole blood samples were collected daily for up to 5 days from patients admitted to the intensive care unit with sepsis. RNA isolated from whole blood samples was assayed on Illumina HT-12 gene expression microarrays consisting of 48,804 probes. Microarray analysis identified 3677 genes as differentially expressed across 5 days between septic patients and healthy controls. Of the 3677 genes, biological pathway analysis identified 86 genes significantly down-regulated in the sepsis patients were present in

ORGANISM(S): Homo sapiens

SUBMITTER: Grant Parnell 

PROVIDER: E-GEOD-54514 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress