The transitional Gene Expression Profiling of Ovarian Follicle Treated with Indomethacin and RU486 in Rats

ABSTRACT: Indomethacin (an inhibitor of prostaglandin synthesis) and RU486 (mifepristone, progesterone receptor antagonist) are well known compounds which impair follicle rupture in rats, nevertheless the histopahotlogical figures of these follicle were different in detail due to the difference of the pathway which each compound inhibits. To characterize these unruptured follicles further and to investigate the genes which were altered in each rat treated with indomethacin or mifepristone, gene expression profile in ovarian follicle were analyzed in female sprague-Dawley rats. Peri- or post ovulatory follicles were collected by laser microdissection and extracted RNA was analyzed by genechip after single dosage of mifepristone or indomethacin. Animals were singly administered orally Indomethacin (IM

ORGANISM(S): Rattus norvegicus

SUBMITTER: Kenjiro Tsubota 

PROVIDER: E-GEOD-54584 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress