Global transcriptional Analysis of Yap/Yki Orthologs in Drosophila melanogaster by RNA Seq

ABSTRACT: Throughout Metazoa, developmental processes are controlled by a surprisingly limited number of conserved signaling pathways. Precisely how these signaling cassettes were assembled in early animal evolution remains poorly understood, as do the molecular transitions that potentiated the acquisition of their myriad developmental functions. Here we analyze the molecular evolution of the proto-oncogene YAP/Yorkie, a key effector of the Hippo signaling pathway that controls organ size in both Drosophila and mammals. Based on heterologous functional analysis of evolutionarily distant Yap/Yorkie orthologs, we demonstrate that a structurally distinct interaction interface between Yap/Yorkie and its partner TEAD/Scalloped became fixed in the eumetazoan common ancestor. We then combine transcripti

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Chris Seidel 

PROVIDER: E-GEOD-54600 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress