Glucocorticoid-induced reversal of IL1b stumulated gene expression in OE-E6/7 cells

ABSTRACT: Studies indicate that high-grade serous ovarian carcinoma (HGSOC), the most common epithelial ovarian carcinoma histotype, originates from the fallopian tube epithelium (FTE). Risk factors for this cancer include reproductive parameters associated with lifetime ovulatory events. Ovulation is an acute inflammatory process during which the FTE is exposed to follicular fluid containing both pro- and anti-inflammatory molecules, such as interleukin-1 (IL1), tumor necrosis factor (TNF), and cortisol. Repeated exposure to inflammatory cytokines may contribute to transforming events in the FTE, with glucocorticoids exerting a protective effect. The global response of FTE cells to inflammatory cytokines or glucocorticoids has not been investigated. To examine the response of FTE cells and the

ORGANISM(S): Homo sapiens

SUBMITTER: carl virtanen 

PROVIDER: E-GEOD-54608 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress