Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation

ABSTRACT: MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of highly invasive tumors when subcutaneously injected in nude mice. Nevertheless, the molecular mechanism underlying the oncogenic activity of P252H mutant remained elusive.In this work, we performed Illumina Whole Genome arrays on three biological replicas of human HEK293 cells stably transfected with the wild-type MLK3, the P252H mutation and with the empty vector (Mock) in order to identify the putative signaling pathways associated with P252H Our results showed that mutant MLK3 exerts its oncogenic effects by

ORGANISM(S): Homo sapiens

SUBMITTER: Danilo Licastro 

PROVIDER: E-GEOD-54611 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress