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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Fatima Al-Shahrour

PROVIDER: E-GEOD-54646 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis.

Rampal Raajit R Al-Shahrour Fatima F Abdel-Wahab Omar O Patel Jay P JP Brunel Jean-Philippe JP Mermel Craig H CH Bass Adam J AJ Pretz Jennifer J Ahn Jihae J Hricik Todd T Kilpivaara Outi O Wadleigh Martha M Busque Lambert L Gilliland D Gary DG Golub Todd R TR Ebert Benjamin L BL Levine Ross L RL

Blood 20140416 22

Genomic studies have identified somatic alterations in the majority of myeloproliferative neoplasms (MPN) patients, including JAK2 mutations in the majority of MPN patients and CALR mutations in JAK2-negative MPN patients. However, the role of JAK-STAT pathway activation in different MPNs, and in patients without JAK2 mutations, has not been definitively delineated. We used expression profiling, single nucleotide polymorphism arrays, and mutational profiling to investigate a well-characterized c ...[more]

PMID: 24740812

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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines]

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Project description:This SuperSeries is composed of the SubSeries listed below.

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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [MPN patients]

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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [MPN patients]

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