Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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A pivotal role of SRC-2 in Metastatic and Castration Resistant Prostate Cancer

ABSTRACT: SRC-2 is frequently amplified or overexpressed in metastatic prostate cancer patients. In this study, we used genetically engineered mice, overexpressing SRC-2 specifically in the prostate epithelium as a mouse model to examine the role of SRC-2 in prostate tumorigenesis. Over-expression of SRC-2 in PTEN heterozygous mice accelerates PTEN mutation induced tumor progression and develops a metastasis-prone cancer. We used microarrays to examine the molecular profile of prostate-specific SRC-2 overexpression adult dorsal-lateral prostate in comparison with that of control PTENF/+ heterozygous deletion mice. Total RNA was extracted from dorsal-lateral prostate of 7 months old-PTEN flox/+ control and PTEN flox/+; Rosa26-SRC-2 OE/+ adult mice, followed by gene expression profiling using Affymetrix microarrays. Each sample contains pooled prostate RNA from 3 mice.

ORGANISM(S): Mus musculus

SUBMITTER: Hui-Ju Lee 

PROVIDER: E-GEOD-54678 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer.

Qin Jun J   Lee Hui-Ju HJ   Wu San-Pin SP   Lin Shih-Chieh SC   Lanz Rainer B RB   Creighton Chad J CJ   DeMayo Francesco J FJ   Tsai Sophia Y SY   Tsai Ming-Jer MJ  

The Journal of clinical investigation 20141008 11

A major clinical hurdle for the management of advanced prostate cancer (PCa) in patients is the resistance of tumors to androgen deprivation therapy (ADT) and their subsequent development into castration-resistant prostate cancer (CRPC). While recent studies have identified potential pathways involved in CRPC development, the drivers of CRPC remain largely undefined. Here we determined that nuclear receptor coactivator 2 (NCoA2, also known as SRC-2), which is frequently amplified or overexpresse  ...[more]

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