Identification of MglA-regulated genes reveals novel virulence factors in F. tularensis

ABSTRACT: The facultative intracellular bacterium Francisella tularensis causes the zoonotic disease tularemia. F. tularensis resides within host macrophages in vivo and this ability is essential for pathogenesis. The transcription factor MglA is required for expression of several Francisella genes that are necessary for replication in macrophages and for virulence in mice. We hypothesized that identification of MglA-regulated genes in the Francisella genome by transcriptional profiling of wild-type and mglA mutant bacteria would lead to the discovery of new virulence factors utilized by F. tularensis. One hundred and two MglA-regulated genes were identified, the majority of which were positively regulated, including all of the Francisella Pathogenicity Island (FPI) genes. We mutated novel MglA

ORGANISM(S): Francisella tularensis

SUBMITTER: Anna Brotcke 

PROVIDER: E-GEOD-5468 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress