Genistein Protects Hematopoietic Stem Cells against G-CSF-Induced DNA Damage

ABSTRACT: Granulocyte colony-stimulating factor (G-CSF) has been utilized to treat neutropenia in various clinical settings. Although clearly beneficial, there are concerns that use of G-CSF in certain conditions increases the risk of myelodysplastic syndrome (MDS) and/or acute myeloid leukemia (AML). The most striking example is in severe congenital neutropenia (SCN). SCN patients develop MDS/AML at a high rate that is directly correlated to the cumulative lifetime dosage of G-CSF. MDS and AML that arise in these settings are commonly associated with chromosomal deletions. We demonstrate that chronic G-CSF treatment in mice results in expansion of the hematopoietic stem cell population. Furthermore, primitive hematopoietic progenitors from G-CSFM-bM-^@M-^Streated mice show evidence of DNA damage as

ORGANISM(S): Mus musculus

SUBMITTER: Liliana Souza 

PROVIDER: E-GEOD-54737 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress