Characterization of the connection between protein synthesis and amino acid biosynthesis gene expression to growth rate in budding yeast

ABSTRACT: In unicellular organisms, growth rate is the major phenotype that is being selected through evolution. In order to grow efficiently, living cells should synchronize the quantity of their ribosome and RNA polymerase levels according to the respective rates by which amino acids and nucleotides pool are replenished. Gene expression patterns and their relationship with growth rate have been widely investigated in various conditions, and a large set of transcripts which included genes associated with ribosome biogenesis (Ribi) and with the stress response, was shown to be expressed in coordination with cell growth rate. Interestingly, decoupling of this correlation was found for certain mutants and conditions, including in my lab when mutant growth rate was examined and when yeast were grown

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Noam Ohana 

PROVIDER: E-GEOD-54748 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress