Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

13 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MRNA expression in blood of 18 schizophrenia patients and 12 healthy controls

ABSTRACT: The study profiles genome-wide mRNA expression in blood from 18 early-onset SZ (EOS) cases and 12 healthy controls. A total of 1070 mRNAs were detected by the microarrays in our samples. 18 schizophrenia samples and 12 healthy controls were used to acquire blood expression profiles

ORGANISM(S): Homo sapiens

SUBMITTER: Fuquan Zhang

PROVIDER: E-GEOD-54913 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Converging evidence implicates the abnormal microRNA system in schizophrenia.

Zhang Fuquan F Xu Yong Y Shugart Yin Yao YY Yue Weihua W Qi Guoyang G Yuan Guozhen G Cheng Zaohuo Z Yao Jianjun J Wang Jidong J Wang Guoqiang G Cao Hongbao H Guo Wei W Zhou Zhenhe Z Wang Zhiqiang Z Tian Lin L Jin Chunhui C Yuan Jianmin J Liu Chenxing C Zhang Dai D

Schizophrenia bulletin 20141126 3

<h4>Background</h4>Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation of brain development through microRNA (miRNA) systems.<h4>Methods</h4>This study aims to (1) compare the overall frequency of 121 rare variants (RVs) in 59 genes associated with the miRNA system in genome-wide association studies (GWAS)-derived data including 768 SZ cases and 1348 healthy controls and validated in ...[more]

PMID: 25429046

Similar Datasets

mRNA expression in blood of 18 schizophrenia patients and 12 healthy controls

Project description:The study profiles genome-wide mRNA expression in blood from 18 early-onset SZ (EOS) cases and 12 healthy controls. A total of 1070 mRNAs were detected by the microarrays in our samples.

2014-12-05 | GSE54913 | GEO

miRNA expression in blood of 15 schizophrenia patients and 15 healthy controls

Project description:The study profiles genome-wide miRNA expression in blood from 15 early-onset SZ (EOS) cases and 15 healthy controls. A total of 1070 miRNAs were detected by the microarrays in our samples. We profiles miRNA expression in 15 schizophrenia samples and 15 healthy controls to explore the alteration of miRNAs in schizophrenia.

2014-12-02 | GSE54578 | GEO

Tenacibaculum sp. SZ-18 isolate:SZ-18

Project description:Tenacibaculum sp. SZ-18 isolate:SZ-18 Genome sequencing

| PRJNA357129 | ENA

Expression in blood of schizophrenia patients and healthy controls

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-12-05 | E-GEOD-54914 | biostudies-arrayexpress

Placental gene-expression profiles of Intrahepatic cholestasis of pregnancy (ICP)

Project description:DNA microarray was applied to characterize the whole-genome expression profiles of placentas during ICP development. Pregnant women were categorized evenly into three groups: healthy group; mild ICP, with serum bile-acid concentration ranging from 10M-bM-^@M-^S40 uM; and severe ICP, with bile-acid concentration >40 uM.

2013-04-18 | E-GEOD-46157 | biostudies-arrayexpress

Transcriptomic analysis of WT versus Ikzf4-/- CD4+ T cells cultured in Th2-polarizing conditions

Project description:The Ikaros zinc finger transcription factor Eos has been commonly implicated in regulatory T cells to promote their immunosuppressive functions. Paradoxically, a new role is emerging for Eos in promoting pro-inflammatory responses of conventional CD4+ T cells in the dysregulated setting of autoimmunity. Even so, the precise role of Eos in regulating the differentiation and function of healthy effector CD4+ T cell subsets remains unclear. Here, we find that Eos is a positive regulator of CD4+ T helper 2 (TH2) cells—effector T cells implicated in the induction of allergic asthma. Using murine in vitro TH2 cells and an in vivo house dust mite asthma model, we found that Eos-deficient T cells had reduced expression of key TH2 transcription factors, effector cytokines, and differentiation receptors. Mechanistically, among various TH2-polarizing pathways, the IL-2/STAT5 axis and its downstream TH2 gene targets emerged as one of the most significantly downregulated networks in Eos deficiency. Using in vitro TH2 cells and overexpression of Eos zinc-finger-domain mutants, we discovered that Eos forms a novel complex with and supports the tyrosine-phosphorylated signaling activity of STAT5. Overall, these data define a novel regulatory mechanism whereby Eos promotes IL-2/STAT5 activity to facilitate TH2 differentiation.

2023-02-01 | GSE216737 | GEO

Differential gene expression analysis in motor and sensory cortex as a result of experimental autoimmune encephalomyelitis (EAE), a neuroinflammatory model for Multiple sclerosis.

Project description:We performed micrarrays to investigate neuronal gene expression changes during acute inflammatory CNS axon injury using the murine myelin oligodendrocyte glycoprotein 35-55 (MOG35-55)-induced experimental autoimmune encephalomyelitis (EAE) model. The present study was assigned to assess the direct and indirect endogenous neuronal response to spinal axonal injury in the motor and sensory cortex. Gene expression in motor and sensory cortex enriched tissue was assessed from four healthy and six EAE female mice. Tissue was collected from mice with paraplegia or monoplegia, with contralateral hindlimb paresis (EAE day 18-21). The gene expression profiles of the EAE mice were compared to the motor or sensory cortex of healthy control mice, resulting in a list of differentially expressed genes in healthy and EAE mice.

2014-10-01 | E-GEOD-47900 | biostudies-arrayexpress

Transcription profiling by array of fibroblasts from eight individuals to evaluate variability in the establishment of induced pluripotent stem cell lines and to develop future cellular models of disease.

Project description:Fibroblasts from eight individuals were chosen to evaluate variability in the establishment of iPSC lines and to develop future cellular models of disease. From the eight patients four were healthy controls (Cont) and four were schizophrenic (Sz). All the patients were males with ages ranging from 21-51 and both groups (Cont vs Sz), were age matched. Primary fibroblasts were reprogrammed using lentivirus expressing Oct4, Sox2, Klf4 and cMyc

2012-09-29 | E-MTAB-1040 | biostudies-arrayexpress

lncRNA expression profiles for preterm premature rupture of membrane (PPROM)

Project description:Investigation of lncRNA expression profile of PPROM Arraystar Human LncRNA Array v2.0 was applied to study 40 placentas.

2013-12-18 | E-GEOD-50879 | biostudies-arrayexpress

Development of gene expression signatures for mesenchymal stem cells from neuroblastoma patients

Project description:To obtain genetic evidence about the interaction between MSCs and metastatic NB cancer cells in bone marrow (BM), we isolated bone marrow-derived MSCs from children with NB and compared their global expression patterns with MSCs obtained from normal pediatric donors using the Agilent 44K microarrays. A total of eight different donors (four NB patients and four healthy donors) were analyzed and three independent microarrays hybridizations were performed for each donor.

2012-06-30 | E-GEOD-35133 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data